Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957
Identifieur interne : 000081 ( 1957/Analysis ); précédent : 000080; suivant : 000082Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957
Auteurs : Claudia Pappas [États-Unis] ; Karthik Viswanathan [États-Unis] ; Aarthi Chandrasekaran [États-Unis] ; Rahul Raman [États-Unis] ; Jacqueline M. Katz [États-Unis] ; Ram Sasisekharan [États-Unis] ; Terrence M. Tumpey [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2010.
Descripteurs français
- KwdFr :
- Analyse sur microréseau, Animaux, Conformation des protéines, Flambées de maladies, Furets, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe chez les oiseaux (transmission), Grippe chez les oiseaux (virologie), Grippe humaine (transmission), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Hémagglutination, Modèles moléculaires, Mutation, Mâle, Oiseaux, Polyosides (métabolisme), Respiration, Récepteurs viraux (), Récepteurs viraux (métabolisme), Saisons, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (isolement et purification), Sous-type H2N2 du virus de la grippe A (métabolisme), Spécificité du substrat, Érythrocytes (immunologie).
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H2N2 du virus de la grippe A.
- immunologie : Érythrocytes.
- isolement et purification : Sous-type H2N2 du virus de la grippe A.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza, Polyosides, Récepteurs viraux, Sous-type H2N2 du virus de la grippe A.
- virologie : Grippe chez les oiseaux, Grippe humaine.
- épidémiologie : Grippe chez les oiseaux, Grippe humaine.
- Analyse sur microréseau, Animaux, Conformation des protéines, Flambées de maladies, Furets, Humains, Hémagglutination, Modèles moléculaires, Mutation, Mâle, Oiseaux, Respiration, Récepteurs viraux, Saisons, Spécificité du substrat.
English descriptors
- KwdEn :
- Animals, Birds, Disease Outbreaks, Erythrocytes (immunology), Ferrets, Hemagglutination, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (isolation & purification), Influenza A Virus, H2N2 Subtype (metabolism), Influenza in Birds (transmission), Influenza in Birds (virology), Influenza, Human (epidemiology), Influenza, Human (transmission), Influenza, Human (virology), Male, Microarray Analysis, Models, Molecular, Mutation, Polysaccharides (metabolism), Protein Conformation, Receptors, Virus (chemistry), Receptors, Virus (metabolism), Respiration, Seasons, Substrate Specificity.
- MESH :
- chemical , chemistry : Receptors, Virus.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Erythrocytes.
- isolation & purification : Influenza A Virus, H2N2 Subtype.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H2N2 Subtype, Polysaccharides, Receptors, Virus.
- transmission : Influenza in Birds, Influenza, Human.
- virology : Influenza in Birds, Influenza, Human.
- Animals, Birds, Disease Outbreaks, Ferrets, Hemagglutination, Humans, Male, Microarray Analysis, Models, Molecular, Mutation, Protein Conformation, Respiration, Seasons, Substrate Specificity.
Abstract
Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin (HA) warrants investigation of this subtype due to its pandemic potential. In this study we examined the transmissibility of representative human H2N2 viruses, A/Albany/6/58 (Alb/58) and A/El Salvador/2/57 (ElSalv/57), isolated during the 1957/58 pandemic, in the ferret model. The receptor binding properties of these H2N2 viruses was analyzed using dose-dependent direct glycan array-binding assays. Alb/58 virus, which contains the 226L/228S amino acid combination in the HA and displayed dual binding to both alpha 2,6 and alpha 2,3 glycan receptors, transmitted efficiently to naïve ferrets by respiratory droplets. Inefficient transmission was observed with ElSalv/57 virus, which contains the 226Q/228G amino acid combination and preferentially binds alpha 2,3 over alpha 2,6 glycan receptors. However, a unique transmission event with the ElSalv/57 virus occurred which produced a 226L/228G H2N2 natural variant virus that displayed an increase in binding specificity to alpha 2,6 glycan receptors and enhanced respiratory droplet transmissibility. Our studies provide a correlation between binding affinity to glycan receptors with terminal alpha 2,6-linked sialic acid and the efficiency of respiratory droplet transmission for pandemic H2N2 influenza viruses.
Url:
DOI: 10.1371/journal.pone.0011158
PubMed: 20574518
PubMed Central: 2888575
Affiliations:
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PMC:2888575Le document en format XML
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Technology, Koch Institute of Integrative Cancer Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute of Integrative Cancer Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. 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(metabolism)</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (isolation & purification)</term><term>Influenza A Virus, H2N2 Subtype (metabolism)</term><term>Influenza in Birds (transmission)</term><term>Influenza in Birds (virology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (transmission)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Microarray Analysis</term><term>Models, Molecular</term><term>Mutation</term><term>Polysaccharides (metabolism)</term><term>Protein Conformation</term><term>Receptors, Virus (chemistry)</term><term>Receptors, Virus (metabolism)</term><term>Respiration</term><term>Seasons</term><term>Substrate Specificity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse sur microréseau</term><term>Animaux</term><term>Conformation des protéines</term><term>Flambées de maladies</term><term>Furets</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term><term>Grippe chez les oiseaux (transmission)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe humaine (transmission)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Hémagglutination</term><term>Modèles moléculaires</term><term>Mutation</term><term>Mâle</term><term>Oiseaux</term><term>Polyosides (métabolisme)</term><term>Respiration</term><term>Récepteurs viraux ()</term><term>Récepteurs viraux (métabolisme)</term><term>Saisons</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (isolement et purification)</term><term>Sous-type H2N2 du virus de la grippe A (métabolisme)</term><term>Spécificité du substrat</term><term>Érythrocytes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Erythrocytes</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza A Virus, H2N2 Subtype</term><term>Polysaccharides</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Polyosides</term><term>Récepteurs viraux</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Birds</term><term>Disease Outbreaks</term><term>Ferrets</term><term>Hemagglutination</term><term>Humans</term><term>Male</term><term>Microarray Analysis</term><term>Models, Molecular</term><term>Mutation</term><term>Protein Conformation</term><term>Respiration</term><term>Seasons</term><term>Substrate Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse sur microréseau</term><term>Animaux</term><term>Conformation des protéines</term><term>Flambées de maladies</term><term>Furets</term><term>Humains</term><term>Hémagglutination</term><term>Modèles moléculaires</term><term>Mutation</term><term>Mâle</term><term>Oiseaux</term><term>Respiration</term><term>Récepteurs viraux</term><term>Saisons</term><term>Spécificité du substrat</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin (HA) warrants investigation of this subtype due to its pandemic potential. In this study we examined the transmissibility of representative human H2N2 viruses, A/Albany/6/58 (Alb/58) and A/El Salvador/2/57 (ElSalv/57), isolated during the 1957/58 pandemic, in the ferret model. The receptor binding properties of these H2N2 viruses was analyzed using dose-dependent direct glycan array-binding assays. Alb/58 virus, which contains the 226L/228S amino acid combination in the HA and displayed dual binding to both alpha 2,6 and alpha 2,3 glycan receptors, transmitted efficiently to naïve ferrets by respiratory droplets. Inefficient transmission was observed with ElSalv/57 virus, which contains the 226Q/228G amino acid combination and preferentially binds alpha 2,3 over alpha 2,6 glycan receptors. However, a unique transmission event with the ElSalv/57 virus occurred which produced a 226L/228G H2N2 natural variant virus that displayed an increase in binding specificity to alpha 2,6 glycan receptors and enhanced respiratory droplet transmissibility. Our studies provide a correlation between binding affinity to glycan receptors with terminal alpha 2,6-linked sialic acid and the efficiency of respiratory droplet transmission for pandemic H2N2 influenza viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Munster, V" uniqKey="Munster V">V Munster</name></author><author><name sortKey="Wallensten, A" uniqKey="Wallensten A">A Wallensten</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name></author><author><name sortKey="Clarke, Mj" uniqKey="Clarke M">MJ Clarke</name></author><author><name sortKey="Schonberger, Lb" uniqKey="Schonberger L">LB Schonberger</name></author><author><name sortKey="Arden, Nh" uniqKey="Arden N">NH Arden</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name></author><author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dowdle, Wr" uniqKey="Dowdle W">WR Dowdle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dowdle, Wr" uniqKey="Dowdle W">WR Dowdle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author><author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name></author><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name></author><author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ma, W" uniqKey="Ma W">W Ma</name></author><author><name sortKey="Vincent, Al" uniqKey="Vincent A">AL Vincent</name></author><author><name sortKey="Gramer, Mr" uniqKey="Gramer M">MR Gramer</name></author><author><name sortKey="Brockwell, Cb" uniqKey="Brockwell C">CB Brockwell</name></author><author><name sortKey="Lager, Km" uniqKey="Lager K">KM Lager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindstrom, Se" uniqKey="Lindstrom S">SE Lindstrom</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A Klimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schafer, Jr" uniqKey="Schafer J">JR Schafer</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Suss, J" uniqKey="Suss J">J Suss</name></author><author><name sortKey="Senne, D" uniqKey="Senne D">D Senne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Makarova, Nv" uniqKey="Makarova N">NV Makarova</name></author><author><name sortKey="Kaverin, Nv" uniqKey="Kaverin N">NV Kaverin</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Senne, D" uniqKey="Senne D">D Senne</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name></author><author><name sortKey="Van Hoeven, N" uniqKey="Van Hoeven N">N Van Hoeven</name></author><author><name sortKey="Glaser, L" uniqKey="Glaser L">L Glaser</name></author><author><name sortKey="Solorzano, A" uniqKey="Solorzano A">A Solorzano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name></author><author><name sortKey="Blixt, O" uniqKey="Blixt O">O Blixt</name></author><author><name sortKey="Chen, Lm" uniqKey="Chen L">LM Chen</name></author><author><name sortKey="Pappas, C" uniqKey="Pappas 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uniqKey="Zamarin D">D Zamarin</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephenson, I" uniqKey="Stephenson I">I Stephenson</name></author><author><name sortKey="Wood, Jm" uniqKey="Wood J">JM Wood</name></author><author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name></author><author><name sortKey="Zambon, Mc" uniqKey="Zambon M">MC Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glaser, L" uniqKey="Glaser L">L Glaser</name></author><author><name sortKey="Zamarin, D" uniqKey="Zamarin D">D Zamarin</name></author><author><name sortKey="Acland, Hm" uniqKey="Acland H">HM Acland</name></author><author><name sortKey="Spackman, E" uniqKey="Spackman E">E Spackman</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Pappas, Claudia" sort="Pappas, Claudia" uniqKey="Pappas C" first="Claudia" last="Pappas">Claudia Pappas</name></region><name sortKey="Chandrasekaran, Aarthi" sort="Chandrasekaran, Aarthi" uniqKey="Chandrasekaran A" first="Aarthi" last="Chandrasekaran">Aarthi Chandrasekaran</name><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><name sortKey="Raman, Rahul" sort="Raman, Rahul" uniqKey="Raman R" first="Rahul" last="Raman">Rahul Raman</name><name sortKey="Sasisekharan, Ram" sort="Sasisekharan, Ram" uniqKey="Sasisekharan R" first="Ram" last="Sasisekharan">Ram Sasisekharan</name><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name><name sortKey="Viswanathan, Karthik" sort="Viswanathan, Karthik" uniqKey="Viswanathan K" first="Karthik" last="Viswanathan">Karthik Viswanathan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957
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